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Taken together, it is tempting to speculate that by affecting MDM2, Set7/9 also attenuates the expression of ROS-inducible RelA/MDM2 target genes

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Our results so far indicated that restoring the Nnt WT/WT genotype in islets with a BL/6J background suffice to restore the glucose and FCCP regulation of mitochondrial glutathione oxidation and NAD(P)H levels to a similar extent as that previously observed in BL/6N mice

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